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KMID : 1132720080060010014
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Genomics & Informatics
2008 Volume.6 No. 1 p.14 ~ p.17
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Inbreeding Coefficients in Two Isolated Mongolian Populations - GENDISCAN Study
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Sung Joo-Hon
Lee Mi-Kyeong
Seo Jeong-Sun
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Abstract
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GENDISCAN study (Gene Discovery for Complex traits in Asian population of Northeast area) was designed to incorporate
methodologies which enhance the power to identify genetic variations underlying complex disorders. Use of population isolates as the target population is a unique feather of this study. However, population isolates may have hidden nbreeding structures which can affect the validity of the study. To understand how this issue may affect results of GENDISCAN, we estimated inbreeding coefficients in two study populations in Mongolia. We analyzed the status of Hardy-Weinberg quilibrium (HWE), polymorphism information contents (PIC), heterozygosity, allelic diversity, and inbreeding coefficients, using 317 and 1,044 STR (short tandem repeat) markers in Orkhontuul and Dashbalbar populations. HWE assumptions
were generally met in most markers (88.6% and 94.2% respectively), and single marker PIC ranged between 0.2 and 0.9. Inbreeding coefficients were estimated to be 0.0023 and 0.0021, which are small enough to assure that conventional genetic analysis would work without any specific modification. We concluded that the population isolates used in GENDISCAN study would not present significant inflation of type I errors from inbreeding effects in its gene discovery analysis.
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KEYWORD
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inbreeding coefficient, Mengolian population, STR, HWE, PIC
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